Cells Generated from Autologous Skin Treatment of Sickle Cell Anemia Mouse
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چکیده
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منابع مشابه
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell-like state by introducing combinations of four transcription factors. However, the therapeutic potential of such induced pluripotent stem (iPS) cells remained undefined. By using a humanized sickle cell anemia mouse model, we show that mice can be rescued after transplantation with...
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Previously we demonstrated that sickle erythrocytes sedimenting at high densities after gradient centrifugation contain higher levels of surface immunoglobulin bound in vivo in comparison to low-density erythrocytes from the same patient. The present study examines the possibility that binding of autologous IgG to sickle erythrocytes may be associated with the sickling phenomenon. In the presen...
متن کاملJacob Hanna , iPS Cells Generated from Autologous Skin Treatment of Sickle Cell Anemia Mouse
www.sciencemag.org (this information is current as of January 10, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/318/5858/1920 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1152092/DC1 can be found at...
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